Peculiarities of carbamazepine pharmacogenetics and the most common adverse drug reactions during its use (literature review)

Carbamazepine is widely used for the treatment of epilepsy, trigeminal neuralgia and psychiatric disorders. However, therapy often ineffective, some patients experience adverse drug reactions, which negatively affect both efficacy safety therapy.
 This review systematized presented up-to-date information regarding pharmacokinetics pharmacogenetics carbamazepine, as well most common reactions arising from its use. Knowledge pharmacokinetics, pharmacodynamics carbamazepine necessary to assess effect genetically determined activity cytochrome P450 isoenzymes on this drug. will make it possible develop approaches personalizing selection an effective safe dose in based individual clinical biological parameters.